在上集幸存下来的人被神秘的先知Shot Bus Gus所救，他似乎拥有控制这些畜生的能力，在先知的带领下，幸存者进入下水道，那可通往城市，路上他们得到了空手道专家Jean-Claude Seagal的帮助，并得知这些畜生源自一个叫"The Hive."的地方，于是他们决定发起反击，永远消灭掉这些畜生。
Twelve ordinary people are called for jury duty for a murder case as traumatizing as it is controversial in which a woman stands trial for killing her own blood.
